This presentation explores the integration of Universal Design for Learning (UDL) principles in the design and facilitation of a hands-on science experiment tailored for students with Autism Spectrum Disorder (ASD). Attendees will gain insight into how flexible learning environments, multiple means of engagement, representation, and expression can foster meaningful participation and deeper understanding in STEM education. Through real-world examples and student outcomes, this session will demonstrate how UDL can reduce barriers, support diverse learning needs, and create more inclusive and engaging science experiences for all learners.